Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia

Paul G. Nestor, Toshiaki Onitsuka, Ronald J. Gurrera, Margaret Niznikiewicz, Melissa Frumin, Martha E. Shenton, Robert W. McCarley

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning were examined within the same subjects. The results indicated two distinct, dissociable brain structure-function relationships: (1) reduced left STG volume-positive symptoms-executive deficits; (2) reduced left FG-negative symptoms-facial memory deficits. STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalSchizophrenia research
Volume91
Issue number1-3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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