Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease: A Case Study Compared with Tonsillitis

Seigo Okada, Yuki Kobayashi-Fujiwara, Atsunori Oga, Takashi Furuta, Kenzo Ikemoto, Hironori Fujii, Yasufumi Sakata, Yasuo Suzuki, Shunji Hasegawa, Takeshi Kusuda, Hiroshi Itoh, Hiroshi Yamashita, Shouichi Ohga

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Abstract

Objectives: Retropharyngeal lesions are often associated with Kawasaki disease (KD). A 4-year-old male first presented a peritonsillar and retropharyngeal abscess-like lesion. Surgical tonsillectomy was performed to avoid a risk of mediastinal abscess, but he fulfilled the diagnostic criteria of KD after the operation. This prompted us to perform a histological study on the KD tonsils. Methods: Thehistopathology of the KD tonsil specimens were compared with hypertrophic tonsils obtained from 4 patients with chronic tonsillitis unrelated to KD assessed by the immunostainings. Results: KD tonsils showed small lymphatic follicles and neutrophil infiltration in the peritonsillar muscle layer, with no evidence of vasculitis or abscess formation. The KD tonsils exclusively showed (1) predominant activated CD4+ T cells in the perifollicular interstitium, (2) sparse scattering of CD68+ monocytes/macrophages in the lymphatic follicles, and (3) polyclonal carcinoembryonic antigen-positive cells in the lymphatic follicles and venules with the high endothelial cells. Conclusions: The uniquely distributed immunocytes suggest the inflammatory process of KD involving the pathogen-associated molecules.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalCardiology (Switzerland)
Volume137
Issue number4
DOIs
Publication statusPublished - Jul 1 2017

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Tonsillitis
Mucocutaneous Lymph Node Syndrome
Palatine Tonsil
Abscess
Retropharyngeal Abscess
Peritonsillar Abscess
Lymphatic Vessels
Tonsillectomy
Neutrophil Infiltration
Lymphadenopathy
Carcinoembryonic Antigen
Vasculitis
Monocytes
Endothelial Cells
Macrophages
T-Lymphocytes
Muscles

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease : A Case Study Compared with Tonsillitis. / Okada, Seigo; Kobayashi-Fujiwara, Yuki; Oga, Atsunori; Furuta, Takashi; Ikemoto, Kenzo; Fujii, Hironori; Sakata, Yasufumi; Suzuki, Yasuo; Hasegawa, Shunji; Kusuda, Takeshi; Itoh, Hiroshi; Yamashita, Hiroshi; Ohga, Shouichi.

In: Cardiology (Switzerland), Vol. 137, No. 4, 01.07.2017, p. 237-243.

Research output: Contribution to journalArticle

Okada, S, Kobayashi-Fujiwara, Y, Oga, A, Furuta, T, Ikemoto, K, Fujii, H, Sakata, Y, Suzuki, Y, Hasegawa, S, Kusuda, T, Itoh, H, Yamashita, H & Ohga, S 2017, 'Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease: A Case Study Compared with Tonsillitis', Cardiology (Switzerland), vol. 137, no. 4, pp. 237-243. https://doi.org/10.1159/000467388
Okada, Seigo ; Kobayashi-Fujiwara, Yuki ; Oga, Atsunori ; Furuta, Takashi ; Ikemoto, Kenzo ; Fujii, Hironori ; Sakata, Yasufumi ; Suzuki, Yasuo ; Hasegawa, Shunji ; Kusuda, Takeshi ; Itoh, Hiroshi ; Yamashita, Hiroshi ; Ohga, Shouichi. / Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease : A Case Study Compared with Tonsillitis. In: Cardiology (Switzerland). 2017 ; Vol. 137, No. 4. pp. 237-243.
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