Distribution of basement membrane antigens in human esophageal lesions

An immunohistochemical study

Masaki Mori, Reishi Shimono, Akinori Kido, Hiroyuki Kuwano, Kouhei Akazawa, Keizo Sugimachi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The distribution of basement membrane components, type‐IV collagen and laminin, was studied immunohistochemically in human samples of normal, hyperplastic, dysplastic and carcinomatous esophageal tissue. The expression of basement membrane components in normal, hyperplastic, and mildly and moderately dysplastic mucosa was characterized by a thick, continuous and linear staining pattern. In severe dysplasia and carcinoma in situ, the basement membrane was thinner and occasionally discontinuous. The distribution of basement membrane in invasive carcinomas varied greatly; well‐differentiated, cohesive tumors had a basement membrane, however, poorly‐differentiated tumors showing irregular cords, or individual cell infiltration, lacked this membrane at the tumor‐stromal interface. Many moderately‐differentiated tumors showed probable immature assembly of basement membrane components. The expression of basement membrane was also influenced by the extent of stromal inflammation. The absence or presence (staining pattern) of basement membrane components in esophageal squamous‐cell carcinoma did not correlate with the survival rate, but did correlate with the histologic differentiation of epithelial organization.

Original languageEnglish
Pages (from-to)839-842
Number of pages4
JournalInternational Journal of Cancer
Volume47
Issue number6
DOIs
Publication statusPublished - Jan 1 1991

Fingerprint

Basement Membrane
Antigens
Neoplasms
Staining and Labeling
Carcinoma
Carcinoma in Situ
Laminin
Mucous Membrane
Collagen
Inflammation
Membranes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Distribution of basement membrane antigens in human esophageal lesions : An immunohistochemical study. / Mori, Masaki; Shimono, Reishi; Kido, Akinori; Kuwano, Hiroyuki; Akazawa, Kouhei; Sugimachi, Keizo.

In: International Journal of Cancer, Vol. 47, No. 6, 01.01.1991, p. 839-842.

Research output: Contribution to journalArticle

Mori, Masaki ; Shimono, Reishi ; Kido, Akinori ; Kuwano, Hiroyuki ; Akazawa, Kouhei ; Sugimachi, Keizo. / Distribution of basement membrane antigens in human esophageal lesions : An immunohistochemical study. In: International Journal of Cancer. 1991 ; Vol. 47, No. 6. pp. 839-842.
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