Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model

Toshihiro Sera, Ryosuke Higashi, Hisashi Naito, Takeshi Matsumoto, Masao Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We quantitatively investigated nanoparticle deposition (density: 1.0 g/cm3, diameter: 0.1–1.0 μm) in a pulmonary acinus using computational fluid dynamics. We assumed that acinar flow was induced by the expansion and contraction of the acinar model, with the volume changing sinusoidally with time as the boundary condition. We based the complicated acinar model and volume change on a mammalian lung, and evaluated the distribution of particle depositions through acinar generation based on three dimensional thinning. The maximum Reynolds numbers at the inlet and terminal alveoli were 0.191 and 1.93 × 10−3, respectively. With only gravitational force, particle deposition was strongly affected, except for the 0.1- and 0.2-μm particles, and the 0.8- and 1.0-μm particles were deposited around the inlet due to sedimentation after the beginning of inflation. We found that the 0.1- to 0.4-μm particles were deposited at the distal alveoli and that the deposition was enhanced by both the gravitational and Brownian forces, despite the small terminal velocity. For the 0.1- and 0.2-μm particles in particular, the particles were deposited throughout the acinus. The maximum deposition fraction of each acinar segment reached 1.2% after a single breath, and was higher in the middle generations and at the terminal alveoli.

Original languageEnglish
Pages (from-to)730-739
Number of pages10
JournalInternational Journal of Heat and Mass Transfer
Volume108
DOIs
Publication statusPublished - Jan 1 2017

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breathing
Nanoparticles
alveoli
nanoparticles
Sedimentation
terminal velocity
Computational fluid dynamics
Reynolds number
computational fluid dynamics
Boundary conditions
lungs
contraction
boundary conditions
expansion

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

Cite this

Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model. / Sera, Toshihiro; Higashi, Ryosuke; Naito, Hisashi; Matsumoto, Takeshi; Tanaka, Masao.

In: International Journal of Heat and Mass Transfer, Vol. 108, 01.01.2017, p. 730-739.

Research output: Contribution to journalArticle

Sera, Toshihiro ; Higashi, Ryosuke ; Naito, Hisashi ; Matsumoto, Takeshi ; Tanaka, Masao. / Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model. In: International Journal of Heat and Mass Transfer. 2017 ; Vol. 108. pp. 730-739.
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