Disturbance of the growth hormone-insulin-like growth factor-1 axis associated with poor performance status in patients with solid tumors

Isamu Okamoto, Masaki Munakata, Masaki Miyazaki, Taroh Satoh, Takenori Takahata, Yasushi Takamatsu, Osamu Muto, Kazuhiko Koike, Kunihiko Ishitani, Taketo Mukaiyama, Yuh Sakata, Kazuhiko Nakagawa, Kazuo Tamura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: Hormonal imbalance characterized by excessive production of growth hormone (GH) and a low circulating concentration of insulin-like growth factor (IGF)-1 has been demonstrated in individuals with various serious conditions. However, little is known about changes in the GH-IGF-1 axis in cancer patients. Methods: We prospectively examined the circulating levels of several hormones in 58 patients with solid tumors who were classified according to Eastern Cooperative Oncology Group performance status (PS): PS 0-1, n = 15; PS 2, n = 15; PS 3, n = 15; and PS 4, n = 13. The relations of hormone concentrations, with a focus on the GH-IGF-1 system, to PS were evaluated by Spearman's rank correlation test and regression analysis. Results: The circulating levels of IGF-1, IGF-binding protein-3 and thyroid hormones (total T3 and T4) were inversely correlated with PS score. The concentration of GH was increased irrespective of PS but not statistically significant. The ratio of IGF-I to GH was inversely correlated with PS. The levels of GH and IGF-1 in all patients were also inversely correlated. Conclusions: The present study suggests that the GH-IGF-1 axis is disturbed in patients with cancer.

Original languageEnglish
Article numberhyp155
Pages (from-to)222-226
Number of pages5
JournalJapanese journal of clinical oncology
Volume40
Issue number3
DOIs
Publication statusPublished - Nov 25 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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