Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans

Keisuke Sanematsu, Yuki Nakamura, Masatoshi Nomura, Noriatsu Shigemura, Yuzo Ninomiya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sweet taste thresholds are positively related to plasma leptin levels in normal weight humans: both show parallel diurnal variations and associations with postprandial glucose and insulin rises. Here, we tested whether this relationship also exists in overweight and obese (OW/Ob) individuals with hyperleptinemia. We tested 36 Japanese OW/Ob subjects (body mass index (BMI) > 25 kg/m 2 ) for recognition thresholds for various taste stimuli at seven different time points from 8:00 a.m. to 10:00 p.m. using the staircase methodology, and measured plasma leptin, insulin, and blood glucose levels before each taste threshold measurement. We also used the homeostatic model assessment of insulin resistance (HOMA-IR) to evaluate insulin resistance. The results demonstrated that, unlike normal weight subjects, OW/Ob subjects showed no significant diurnal variations in the recognition thresholds for sweet stimuli but exhibited negative associations between the diurnal variations of both leptin and sweet recognition thresholds and the HOMA-IR scores. These findings suggest that in OW/Ob subjects, the basal leptin levels (~20 ng/mL) may already exceed leptin’s effective concentration for the modulation of sweet sensitivity and that this leptin resistance-based attenuation of the diurnal variations of the sweet taste recognition thresholds may also be indirectly linked to insulin resistance in OW/Ob subjects.

Original languageEnglish
Article number297
JournalNutrients
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2 2018

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Taste Threshold
Leptin
leptin
diurnal variation
taste sensitivity
insulin resistance
Insulin Resistance
insulin
Insulin
Weights and Measures
blood glucose
body mass index
Blood Glucose
Recognition (Psychology)
Body Mass Index
Glucose
glucose

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans. / Sanematsu, Keisuke; Nakamura, Yuki; Nomura, Masatoshi; Shigemura, Noriatsu; Ninomiya, Yuzo.

In: Nutrients, Vol. 10, No. 3, 297, 02.03.2018.

Research output: Contribution to journalArticle

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