Diverse effects of tumor necrosis factor-α on three subclones from human myelomonocytic leukemia cell line ME-1 exhibiting different differentiation stages

Kohsuke Yanagisawa, Ichiro Watanabe, Yasuhiro Inoue, Takahiko Horiuchi, Hitoshi Hasegawa, Masaki Yasukawa, Shigeru Fujita

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of tumor necrosis factor-α (TNF-α) were examined in three subclone cells from human myelomonocytic leukemia cell line ME-1. These three subclone cells exhibit different differentiation stages of the myelomonocytic lineage. TNF-α exerted a growth-suppressive effect on the least mature subclone cells, ME-F2 cells. On the other hand, TNF-α induced the most mature ME-F1 cells and intermediate ME-F3 cells to differentiate along the monocytic pathway. TNF-α also enhanced interferon-γ (IFN-γ)-induced complement C2 production by ME-F1 and ME-F3 cells but did not affect production by differentiated ME-F1 and ME-F3 cells. These results suggest that the diversity of the effects of TNF on subclone cells from ME-1 depends on the stage of cell differentiation.

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalJournal of Interferon and Cytokine Research
Volume16
Issue number9
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

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