Diverse roles of macrophages in intraocular neovascular diseases: A review

Ye Di Zhou, Shigeo Yoshida, Ying Qian Peng, Yoshiyuki Kobayashi, Lu Si Zhang, Luo Sheng Tang

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

● Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.

Original languageEnglish
Pages (from-to)1902-1908
Number of pages7
JournalInternational Journal of Ophthalmology
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 18 2017

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Macrophages
Choroid Diseases
Pathologic Neovascularization
Retinal Neovascularization
Choroidal Neovascularization
Cytokines
Phenotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Zhou, Y. D., Yoshida, S., Peng, Y. Q., Kobayashi, Y., Zhang, L. S., & Tang, L. S. (2017). Diverse roles of macrophages in intraocular neovascular diseases: A review. International Journal of Ophthalmology, 10(12), 1902-1908. https://doi.org/10.18240/ijo.2017.12.18

Diverse roles of macrophages in intraocular neovascular diseases : A review. / Zhou, Ye Di; Yoshida, Shigeo; Peng, Ying Qian; Kobayashi, Yoshiyuki; Zhang, Lu Si; Tang, Luo Sheng.

In: International Journal of Ophthalmology, Vol. 10, No. 12, 18.12.2017, p. 1902-1908.

Research output: Contribution to journalReview article

Zhou, YD, Yoshida, S, Peng, YQ, Kobayashi, Y, Zhang, LS & Tang, LS 2017, 'Diverse roles of macrophages in intraocular neovascular diseases: A review', International Journal of Ophthalmology, vol. 10, no. 12, pp. 1902-1908. https://doi.org/10.18240/ijo.2017.12.18
Zhou, Ye Di ; Yoshida, Shigeo ; Peng, Ying Qian ; Kobayashi, Yoshiyuki ; Zhang, Lu Si ; Tang, Luo Sheng. / Diverse roles of macrophages in intraocular neovascular diseases : A review. In: International Journal of Ophthalmology. 2017 ; Vol. 10, No. 12. pp. 1902-1908.
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