Abstract
● Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
| Original language | English |
|---|---|
| Pages (from-to) | 1902-1908 |
| Number of pages | 7 |
| Journal | International Journal of Ophthalmology |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 18 2017 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
Cite this
Diverse roles of macrophages in intraocular neovascular diseases : A review. / Zhou, Ye Di; Yoshida, Shigeo; Peng, Ying Qian; Kobayashi, Yoshiyuki; Zhang, Lu Si; Tang, Luo Sheng.
In: International Journal of Ophthalmology, Vol. 10, No. 12, 18.12.2017, p. 1902-1908.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Diverse roles of macrophages in intraocular neovascular diseases
T2 - A review
AU - Zhou, Ye Di
AU - Yoshida, Shigeo
AU - Peng, Ying Qian
AU - Kobayashi, Yoshiyuki
AU - Zhang, Lu Si
AU - Tang, Luo Sheng
PY - 2017/12/18
Y1 - 2017/12/18
N2 - ● Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
AB - ● Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
UR - http://www.scopus.com/inward/record.url?scp=85037587987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037587987&partnerID=8YFLogxK
U2 - 10.18240/ijo.2017.12.18
DO - 10.18240/ijo.2017.12.18
M3 - Review article
AN - SCOPUS:85037587987
VL - 10
SP - 1902
EP - 1908
JO - International Journal of Ophthalmology
JF - International Journal of Ophthalmology
SN - 2222-3959
IS - 12
ER -