Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria

Sen Zheng, Kenji Sonomoto

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation.

Original languageEnglish
Pages (from-to)4243-4253
Number of pages11
JournalApplied Microbiology and Biotechnology
Volume102
Issue number10
DOIs
Publication statusPublished - May 1 2018

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Bacteriocins
Secretory Pathway
Gram-Positive Bacteria
Bacteria
Peptides
ATP-Binding Cassette Transporters
Methicillin-Resistant Staphylococcus aureus
Protein Binding
Membrane Proteins
Anti-Bacterial Agents
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria. / Zheng, Sen; Sonomoto, Kenji.

In: Applied Microbiology and Biotechnology, Vol. 102, No. 10, 01.05.2018, p. 4243-4253.

Research output: Contribution to journalReview article

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