Diversity in guanosine 3′,5′-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants

Yuhta Nomura, Atsushi Izumi, Yoshinori Fukunaga, Kensuke Kusumi, Koh Iba, Seiya Watanabe, Yoichi Nakahira, Andreas P.M. Weber, Akira Nozawa, Yuzuru Tozawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The ppGpp signaling system is operative in plant chloroplasts and bacteria. Results: Chloroplast and cytosolic guanylate kinases (GKs) of plants are sensitive and insensitive to ppGpp, respectively, whereas bacterial GKs show diversity in ppGpp sensitivity. Conclusion: GTP biosynthesis in chloroplasts is controlled by ppGpp. Significance: Identification of the targets of ppGpp should provide insight into biological processes regulated by this nucleotide.

Original languageEnglish
Pages (from-to)15631-15641
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
Publication statusPublished - May 30 2014

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Guanylate Kinases
Guanosine
Chloroplasts
Bacteria
Biosynthesis
Guanosine Triphosphate
Biological Phenomena
Nucleotides

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Diversity in guanosine 3′,5′-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants. / Nomura, Yuhta; Izumi, Atsushi; Fukunaga, Yoshinori; Kusumi, Kensuke; Iba, Koh; Watanabe, Seiya; Nakahira, Yoichi; Weber, Andreas P.M.; Nozawa, Akira; Tozawa, Yuzuru.

In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15631-15641.

Research output: Contribution to journalArticle

Nomura, Y, Izumi, A, Fukunaga, Y, Kusumi, K, Iba, K, Watanabe, S, Nakahira, Y, Weber, APM, Nozawa, A & Tozawa, Y 2014, 'Diversity in guanosine 3′,5′-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15631-15641. https://doi.org/10.1074/jbc.M113.534768
Nomura, Yuhta ; Izumi, Atsushi ; Fukunaga, Yoshinori ; Kusumi, Kensuke ; Iba, Koh ; Watanabe, Seiya ; Nakahira, Yoichi ; Weber, Andreas P.M. ; Nozawa, Akira ; Tozawa, Yuzuru. / Diversity in guanosine 3′,5′-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 22. pp. 15631-15641.
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