Diversity in gut bacterial community of school-age children in Asia

Jiro Nakayama, Koichi Watanabe, Jiahui Jiang, Kazunori Matsuda, Shiou Huei Chao, Pri Haryono, Orawan La-Ongkham, Martinus Agus Sarwoko, I. Nengah Sujaya, Liang Zhao, Kang Ting Chen, Yen Po Chen, Hsueh Hui Chiu, Tomoko Hidaka, Ning Xin Huang, Chikako Kiyohara, Takashi Kurakawa, Naoshige Sakamoto, Kenji Sonomoto, Kousuke TashiroHirokazu Tsuji, Ming Ju Chen, Vichai Leelavatcharamas, Chii Cherng Liao, Sunee Nitisinprasert, Endang S. Rahayu, Fa Zheng Ren, Ying Chieh Tsai, Yuan Kun Lee

Research output: Contribution to journalArticlepeer-review

118 Citations (Scopus)

Abstract

Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.

Original languageEnglish
Article number8397
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • General

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