DNA analysis of a case of so-called blood group chimerism

Akiko Tsuji, E. Minakata, T. Kita, K. Umetsu, Noriaki Ikeda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 46-year-old woman who has three children, whose red blood cells exhibit a dual population of groups A and B, was investigated. Her lymphocytes had an XX/XY karyotype and Y chromosome markers were detected from buccal cells and hair root cells in DNA analysis. Three bands were detected in D1S80 VNTR locus (MCT118), two bands from father and one from mother. Her ABO genotype should be genetically AO, however, the PCR-RFLP method revealed a pattern of BO genotype. From these findings, it is concluded that she is a so-called dispermic chimera which is the result of the fertilization by two sperms and that DNA analysis is useful for distinguishing between twin and dispermic chimerism.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJapanese Journal of Legal Medicine
Volume50
Issue number1
Publication statusPublished - Mar 5 1996

Fingerprint

Chimerism
Blood Group Antigens
Genotype
Minisatellite Repeats
Cheek
Y Chromosome
DNA
Karyotype
Genetic Markers
Population Groups
Fertilization
Fathers
Restriction Fragment Length Polymorphisms
Hair
Spermatozoa
Erythrocytes
Mothers
Lymphocytes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Law

Cite this

DNA analysis of a case of so-called blood group chimerism. / Tsuji, Akiko; Minakata, E.; Kita, T.; Umetsu, K.; Ikeda, Noriaki.

In: Japanese Journal of Legal Medicine, Vol. 50, No. 1, 05.03.1996, p. 17-22.

Research output: Contribution to journalArticle

Tsuji, Akiko ; Minakata, E. ; Kita, T. ; Umetsu, K. ; Ikeda, Noriaki. / DNA analysis of a case of so-called blood group chimerism. In: Japanese Journal of Legal Medicine. 1996 ; Vol. 50, No. 1. pp. 17-22.
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