DNA copy number aberrations associated with lymphovascular invasion in upper urinary tract urothelial carcinoma

Taku Misumi, Yoshiaki Yamamoto, Yoshihiro Miyachika, Satoshi Eguchi, Yasuyo Chochi, Motonao Nakao, Kazuhiro Nagao, Takahiko Hara, Shigeru Sakano, Tomoko Furuya, Atsunori Oga, Shigeto Kawauchi, Kohsuke Sasaki, Hideyasu Matsuyama

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Recent studies have reported that lymphovascular invasion (LVI) is a predictor of patient prognosis in upper urinary tract urothelial carcinoma (UUTUC). DNA copy number aberrations (DCNAs) identified by array-based comparative genomic hybridization (aCGH) had not previously been examined in UUTUC. We therefore examined DCNAs in UUTUC and compared them with DCNAs in LVI. We applied aCGH technology using DNA chips spotted with 4,030 BAC clones to 32 UUTUC patients. Frequent copy number gains were detected on chromosomal regions 8p23.1 and 20q13.12, whereas frequent copy number losses were detected on chromosomal regions 13q21.1, 17p13.1, 6q16.3, and 17p11.2. DCNAs occurred more frequently in tumors with LVI than in those without it (P = 0.0002), and this parameter was more closely associated with LVI than with the tumor grade or pT stage. Disease-specific survival rate was higher in tumors without LVI than in those with it (P = 0.0120); however, tumor grade and stage were not significant prognostic factors of patient outcome. These data support our hypothesis that tumors with LVI have more genetic alterations in terms of total numbers of DCNAs than those without, and provide proof that aggressive adjuvant therapy should be considered for UUTUC patients with LVI.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalCancer Genetics
Volume205
Issue number6
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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