DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

Akihiko Ono, Akira Ito, Taiga Suzuki, Masaki Yamaguchi, Yoshinori Kawabe, Masamichi Kamihira

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume120
Issue number4
DOIs
Publication statusPublished - Oct 1 2015

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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