DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Pengju Pan, Masahiro Fujita, Wei Yang Ooi, Kumar Sudesh, Tohru Takarada, Atsushi Goto, Mizuo Maeda

Research output: Contribution to journalArticle

38 Citations (Scopus)


Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

Original languageEnglish
Pages (from-to)895-900
Number of pages6
Issue number4
Publication statusPublished - Feb 17 2011

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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