Abstract
Background. Biological characteristics of gastric cancer depend mostly on genetic alterations in the cancer cells of individuals. To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case. Methods. We have reviewed the most important results of studies on DNA ploidy of gastric cancer published in the English literature during the last 2 decades. Results. Gastric carcinoma with aneuploidy has been shown to have a high proliferative activity and a high metastatic or invasive potential, thus leading to a poor prognosis as compared to diploid tumors. Conclusion. Analyses of DNA ploidy in gastric cancer may provide clinically useful information on diagnostic, therapeutic, and prognostic aspects. Further investigations may be needed to clarify the relationship between chromosome instability and DNA ploidy.
| Original language | English |
|---|---|
| Pages (from-to) | S63-S70 |
| Journal | Surgery |
| Volume | 131 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Surgery
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DNA ploidy and its clinical implications in gastric cancer. / Baba, Hideo; Korenaga, Daisuke; Kakeji, Yoshihiro; Haraguchi, Masaru; Okamura, Takeshi; Maehara, Yoshihiko.
In: Surgery, Vol. 131, No. 1, 01.01.2002, p. S63-S70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - DNA ploidy and its clinical implications in gastric cancer
AU - Baba, Hideo
AU - Korenaga, Daisuke
AU - Kakeji, Yoshihiro
AU - Haraguchi, Masaru
AU - Okamura, Takeshi
AU - Maehara, Yoshihiko
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Background. Biological characteristics of gastric cancer depend mostly on genetic alterations in the cancer cells of individuals. To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case. Methods. We have reviewed the most important results of studies on DNA ploidy of gastric cancer published in the English literature during the last 2 decades. Results. Gastric carcinoma with aneuploidy has been shown to have a high proliferative activity and a high metastatic or invasive potential, thus leading to a poor prognosis as compared to diploid tumors. Conclusion. Analyses of DNA ploidy in gastric cancer may provide clinically useful information on diagnostic, therapeutic, and prognostic aspects. Further investigations may be needed to clarify the relationship between chromosome instability and DNA ploidy.
AB - Background. Biological characteristics of gastric cancer depend mostly on genetic alterations in the cancer cells of individuals. To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case. Methods. We have reviewed the most important results of studies on DNA ploidy of gastric cancer published in the English literature during the last 2 decades. Results. Gastric carcinoma with aneuploidy has been shown to have a high proliferative activity and a high metastatic or invasive potential, thus leading to a poor prognosis as compared to diploid tumors. Conclusion. Analyses of DNA ploidy in gastric cancer may provide clinically useful information on diagnostic, therapeutic, and prognostic aspects. Further investigations may be needed to clarify the relationship between chromosome instability and DNA ploidy.
UR - http://www.scopus.com/inward/record.url?scp=0036163090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036163090&partnerID=8YFLogxK
U2 - 10.1067/msy.2002.119306
DO - 10.1067/msy.2002.119306
M3 - Article
C2 - 11821789
AN - SCOPUS:0036163090
VL - 131
SP - S63-S70
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 1
ER -