Nuclear DNA content was microspectrophotometrically measured in 18 patients with a mucosal carcinoma of the stomach less than 5 mm in diameter. The findings were compared with data on 56 patients with a lesion greater than 5 mm. DNA distribution patterns were grouped into low and high ploidies. A mucosal carcinoma, classed as high ploidy, was confirmed in 27.8%, 22.2%, and 28.9% of the lesions with a diameter of less than 5 mm, 5 to 20 mm, and 20 to 40 mm, respectively. In the high‐ploidy group with a lesion exceeding 5 mm, there was a preponderance of an elevated lesion, well‐ and moderately differentiated adenocarcinomas, and location in the lower third of the stomach. Such pathologic features showed the same tendency in the high‐ploidy group with a lesion less than 5 mm. An aneuploid carcinoma may be present even in a lesion confined to the mucosa, and less than 5 mm in diameter.
|Number of pages||4|
|Publication status||Published - Dec 1 1986|
All Science Journal Classification (ASJC) codes
- Cancer Research