DNA ploidy is a major prognostic factor in advanced gastric carcinoma- univariate and multivariate analysis

M. Haraguchi, A. Watanabe, S. Moriguchi, D. Korenaga, Y. Maehara, T. Okamura, K. Sugimachi

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23 Citations (Scopus)

Abstract

DNA ploidy was determined by cytofluorometric analysis of paraffin- embedded malignant tissue from 96 Japanese patients in whom gastric carcinoma had invaded the serosa. Aneuploidy was found in gastric carcinoma tissue from 63 patients (66%). The postoperative 5-year survival rate of patients with aneuploid malignancy was significantly lower (13%) than those with diploid malignancy (36%) (p < 0.05). A multivariate analysis of various clinical and pathologic factors showed that tumor size, lymph node metastasis, vascular invasion, and DNA ploidy were significant and independent factors, which correlated with prognosis.

Original languageEnglish
Pages (from-to)814-819
Number of pages6
JournalSurgery
Volume110
Issue number5
Publication statusPublished - Dec 1 1991

All Science Journal Classification (ASJC) codes

  • Surgery

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    Haraguchi, M., Watanabe, A., Moriguchi, S., Korenaga, D., Maehara, Y., Okamura, T., & Sugimachi, K. (1991). DNA ploidy is a major prognostic factor in advanced gastric carcinoma- univariate and multivariate analysis. Surgery, 110(5), 814-819.