DNA ploidy is associated with growth potential in gastric carcinoma

Masaru Haraguchi, Daisuke Korenaga, Yoshihiro Kakeji, Hiroyuki Orita, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To correlate growth potential with DNA ploidy 109 patients with early gastric carcinoma and 132 patients with advanced gastric carcinoma were studied. Early gastric carcinomas were classified by growth potential into the small mucosal type, the superficially spreading (super) type, or the expansively penetrating (Pen A)/ infiltratively penetrating (Pen B) types. Advanced gastric carcinomas were classified into funnel, column, or mountain types, each of which was divided further into expanding and infiltrative types. Cell nuclear DNA content was measured by microspectrophotometric study and classified as either low or high ploidy according to the degree of dispersion on the DNA histogram. Super type early and funnel type advanced carcinomas, characterized by superficially spreading growth, were more likely to have low DNA ploidy. In contrast, Pen A type early and column‐expanding type advanced carcinomas, characterized by expansively penetrating growth, were more likely to have high DNA ploidy. Cancer 68:2608–2611, 1991.

Original languageEnglish
Pages (from-to)2608-2611
Number of pages4
JournalCancer
Volume68
Issue number12
DOIs
Publication statusPublished - Dec 15 1991

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Haraguchi, M., Korenaga, D., Kakeji, Y., Orita, H., Maehara, Y., & Sugimachi, K. (1991). DNA ploidy is associated with growth potential in gastric carcinoma. Cancer, 68(12), 2608-2611. https://doi.org/10.1002/1097-0142(19911215)68:12<2608::AID-CNCR2820681215>3.0.CO;2-Y