DNA ploidy pattern and p53 overexpression in gastric cancer

S. Tomisaki, O. Tatsuo, O. Hisao, Y. Sakaguchi, T. Kusumoto, S. Ohno, Y. Ichiyoshi, Y. Maehara, K. Sugimachi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

DNA ploidy pattern was determined by flow cytometry and p53 overexpression was investigated immunohistochemically in 145 primary gastric cancers. Aneuploid patterns were found in 78 (65%) and diploid patterns in 67 (46%). Metastasising to lymph nodes was observed more frequently in cases with aneuploid tumors, as compared to those with diploid tumors (p < 0.01). DNA ploidy patterns were related to overexpression of p53. The incidences of overexpression of p53 in aneuploid tumors and diploid ones were 65% and 33%, respectively (p < 0.05). Thus, we suggest that gastric carcinomas with the aneuploid pattern have mutation of tumor suppressor gene p53 and high potential to metastasize to lymph nodes.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume22 Suppl 2
Publication statusPublished - Jun 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'DNA ploidy pattern and p53 overexpression in gastric cancer'. Together they form a unique fingerprint.

Cite this