DNA ploidy pattern and p53 overexpression in gastric cancer

S. Tomisaki, O. Tatsuo, O. Hisao, Y. Sakaguchi, T. Kusumoto, S. Ohno, Y. Ichiyoshi, Y. Maehara, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

DNA ploidy pattern was determined by flow cytometry and p53 overexpression was investigated immunohistochemically in 145 primary gastric cancers. Aneuploid patterns were found in 78 (65%) and diploid patterns in 67 (46%). Metastasising to lymph nodes was observed more frequently in cases with aneuploid tumors, as compared to those with diploid tumors (p < 0.01). DNA ploidy patterns were related to overexpression of p53. The incidences of overexpression of p53 in aneuploid tumors and diploid ones were 65% and 33%, respectively (p < 0.05). Thus, we suggest that gastric carcinomas with the aneuploid pattern have mutation of tumor suppressor gene p53 and high potential to metastasize to lymph nodes.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume22 Suppl 2
Publication statusPublished - Jun 1995

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Ploidies
Aneuploidy
Stomach Neoplasms
Diploidy
DNA
Lymph Nodes
Neoplasms
Tumor Suppressor Genes
Stomach
Flow Cytometry
Carcinoma
Mutation
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tomisaki, S., Tatsuo, O., Hisao, O., Sakaguchi, Y., Kusumoto, T., Ohno, S., ... Sugimachi, K. (1995). DNA ploidy pattern and p53 overexpression in gastric cancer. Gan to kagaku ryoho. Cancer & chemotherapy, 22 Suppl 2, 115-117.

DNA ploidy pattern and p53 overexpression in gastric cancer. / Tomisaki, S.; Tatsuo, O.; Hisao, O.; Sakaguchi, Y.; Kusumoto, T.; Ohno, S.; Ichiyoshi, Y.; Maehara, Y.; Sugimachi, K.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 22 Suppl 2, 06.1995, p. 115-117.

Research output: Contribution to journalArticle

Tomisaki, S, Tatsuo, O, Hisao, O, Sakaguchi, Y, Kusumoto, T, Ohno, S, Ichiyoshi, Y, Maehara, Y & Sugimachi, K 1995, 'DNA ploidy pattern and p53 overexpression in gastric cancer', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 22 Suppl 2, pp. 115-117.
Tomisaki S, Tatsuo O, Hisao O, Sakaguchi Y, Kusumoto T, Ohno S et al. DNA ploidy pattern and p53 overexpression in gastric cancer. Gan to kagaku ryoho. Cancer & chemotherapy. 1995 Jun;22 Suppl 2:115-117.
Tomisaki, S. ; Tatsuo, O. ; Hisao, O. ; Sakaguchi, Y. ; Kusumoto, T. ; Ohno, S. ; Ichiyoshi, Y. ; Maehara, Y. ; Sugimachi, K. / DNA ploidy pattern and p53 overexpression in gastric cancer. In: Gan to kagaku ryoho. Cancer & chemotherapy. 1995 ; Vol. 22 Suppl 2. pp. 115-117.
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