DNA trapping at the interface of nanopillar and nanopillar-free regions for long DNA separation

Koki Motoyama, Takao Yasui, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a technique of DNA separation based on DNA dynamics at the interface of nanopillar and nanopillar-free regions in nanopillar array chips. We investigated the residence time of DNA molecules at the interface of nanopillar and nanopillar-free regions, and revealed that DNA molecules were trapped at the interface by entirely introducing DNA molecules from nanopillar-free to nanopillar regions. The separation of DNA molecules could be achieved within five seconds based on the difference of residence time of each DNA.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages647-649
Number of pages3
Publication statusPublished - Dec 1 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'DNA trapping at the interface of nanopillar and nanopillar-free regions for long DNA separation'. Together they form a unique fingerprint.

  • Cite this

    Motoyama, K., Yasui, T., Kaji, N., Okamoto, Y., Tokeshi, M., & Baba, Y. (2011). DNA trapping at the interface of nanopillar and nanopillar-free regions for long DNA separation. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 647-649). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).