DNA typing of HLA class I (HLA-A) and class II genes (HLA-DR, -DQ and -DP) in Japanese patients with gastric cancer

M. Ohmori, S. Yasunaga, Yoshihiko Maehara, K. Sugimachi, Takehiko Sasazuki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Gastric cancer is multifactorial disease and several reports have described genetic factors involved in pathogenesis of gastric cancer. Recently, it was reported that HLA class II gene DQB1(*)0301 was strongly associated with gastric cancer in Caucasian population (20). We performed DNA typing of HLA class I (HLA-A) and HLA class II genes (HLA-DR, DQ and DP) to elucidate the HLA alleles or HLA haplotypes associated with gastric cancer in Japanese population using polymerase chain reaction-sequence-specific oligonucleotide probe analysis in 88 unrelated patients with gastric cancer and 525 unrelated healthy controls. We observed slight difference in frequencies of some HLA alleles and haplotypes between gastric cancer patients and controls; however, after Bonferroni correction, statistical significance was not confirmed. It is possible that environmental factors such as diet cover the contribution of genetic factors to the disease in Japanese population, which has a higher frequency of gastric cancer than do Caucasian populations, most likely due to more exposure to environmental risk factors.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalTissue antigens
Volume50
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

HLA-DQ Antigens
MHC Class II Genes
HLA-A Antigens
DNA Fingerprinting
HLA-DR Antigens
Stomach Neoplasms
Genes
Oligonucleotide Probes
Polymerase chain reaction
DNA
Nutrition
Haplotypes
Population
Alleles
HLA-DP Antigens
Environmental Exposure
Diet
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

DNA typing of HLA class I (HLA-A) and class II genes (HLA-DR, -DQ and -DP) in Japanese patients with gastric cancer. / Ohmori, M.; Yasunaga, S.; Maehara, Yoshihiko; Sugimachi, K.; Sasazuki, Takehiko.

In: Tissue antigens, Vol. 50, No. 3, 01.01.1997, p. 277-282.

Research output: Contribution to journalArticle

Ohmori, M. ; Yasunaga, S. ; Maehara, Yoshihiko ; Sugimachi, K. ; Sasazuki, Takehiko. / DNA typing of HLA class I (HLA-A) and class II genes (HLA-DR, -DQ and -DP) in Japanese patients with gastric cancer. In: Tissue antigens. 1997 ; Vol. 50, No. 3. pp. 277-282.
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