DNA typing of HLA‐B gene in Takayasu's Arteritis

Masayuki Yoshida, Akineri Kimura, Kiyanari Katsuragi, Fujia Numano, Takohlko Sasazuki

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68 Citations (Scopus)

Abstract

Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of 63Glu and 67Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalTissue antigens
Volume42
Issue number1
DOIs
Publication statusPublished - Jul 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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