DNA typing of HLA‐B gene in Takayasu's Arteritis

Masayuki Yoshida; Akineri Kimura; Kiyanari Katsuragi; Fujia Numano; Takohlko Sasazuki

doi:10.1111/j.1399-0039.1993.tb02172.x

DNA typing of HLA‐B gene in Takayasu's Arteritis

Masayuki Yoshida, Akineri Kimura, Kiyanari Katsuragi, Fujia Numano, Takohlko Sasazuki

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of ⁶³Glu and ⁶⁷Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, ⁶³Glu and ⁶⁷Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Tissue antigens
Volume	42
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.1993.tb02172.x
Publication status	Published - Jul 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Biochemistry
Genetics

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title = "DNA typing of HLA‐B gene in Takayasu's Arteritis",

abstract = "Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of 63Glu and 67Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard",

author = "Masayuki Yoshida and Akineri Kimura and Kiyanari Katsuragi and Fujia Numano and Takohlko Sasazuki",

year = "1993",

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AU - Yoshida, Masayuki

AU - Kimura, Akineri

AU - Katsuragi, Kiyanari

AU - Numano, Fujia

AU - Sasazuki, Takohlko

PY - 1993/7

Y1 - 1993/7

N2 - Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of 63Glu and 67Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard

AB - Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of 63Glu and 67Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard

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