Docetaxel/ TS-1 with radiation for unresectable squamous cell carcinoma of the esophagus - A phase II trial

Hideo Matsumoto, Hisako Kubota, Masaharu Higashida, Eisaku Yoden, Junichi Hiratsuka, Ken Haruma, Masafumi Nakamura, Toshihiro Hirai

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: We tried a new regimen of docetaxel / TS-1 (tegafur-gimestat-otastat potassium) combined with radiation for squamous cell carcinoma of the esophagus in a phase II trial. Patients and Methods: The patients, whose tumor invaded other organs without other organ metastasis, were given TS-1 (60 mg/m2/day) from days 1 to 14, and docetaxel (20-30 mg/m2) on days 1 and 8. They received radiation in 2.0 Gy from days 1 to 21. Patients were given a seven-day rest after the first course, and then were treated with the same regimen from days 28 to 49. Results: Seventeen cases were enrolled in the study. The response rate was 76.4% (13/17). The overall 5-year survival rate was 29.6% (5/17) and median survival time was 15.2 months. Adverse events more than grade 3 occurred in 10 cases. Conclusion: This combination therapy may be one of the most effective treatments because of its lower rate of non-hematological adverse events and higher response rate. Three cases also underwent salvage surgery when the tumor recurred, and in one case, chemoradiation to a metastatic nodule on the thoracic wall was added.

Original languageEnglish
Pages (from-to)3759-3763
Number of pages5
JournalAnticancer research
Volume34
Issue number7
Publication statusPublished - Jul 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Docetaxel/ TS-1 with radiation for unresectable squamous cell carcinoma of the esophagus - A phase II trial'. Together they form a unique fingerprint.

Cite this