Does a combination pill of antihypertensive drugs improve medication adherence in Japanese?-a randomized controlled trial

Kiyoshi Matsumura, Hisatomi Arima, Mitsuhiro Tominaga, Toshio Ohtsubo, Toshiyuki Sasaguri, Koji Fujii, Masayo Fukuhara, Keiko Uezono, Yuki Morinaga, Yuko Ohta, Takatoshi Otonari, Junya Kawasaki, Isao Kato, Takuya Tsuchihashi

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18 Citations (Scopus)

Abstract

Background: In order to achieve target blood pressure levels to prevent cardiovascular disease, combination therapy of antihypertensive drugs is often required, although it is thought that requiring a patient to take many different pills would reduce adherence to the medication regimen. Whether antihypertensive treatment with a single pill combining antihypertensive drugs would improve medication adherence and blood pressure control was investigated. Methods and Results: A total of 207 hypertensive subjects were randomly assigned to a combination pill group (losartan 50 mg/hydrochlorothiazide 12.5 mg; n=103) or a control group (an angiotensin receptor blocker and a thiazide diuretic; n=104). Medication adherence was evaluated by pill counts at 1, 3, and 6 months after randomization. The mean adherence rates over 6 months were not different between the 2 groups: 98% in the combination pill group and 98% in the control group. Moreover, the 2 groups included similar numbers of subjects with relatively poor adherence rates (<90%) in each treatment period. The mean blood pressures over the 6-month treatment period were not different between the groups: 131/75 mmHg in the combination pill group and 130/75 mmHg in the control group (P=0.84/0.96). Conclusions: There were no appreciable effects of the combination pill of antihypertensive drugs on medication adherence or blood pressure control in Japanese patients over a 6-month period.

Original languageEnglish
Pages (from-to)1415-1422
Number of pages8
JournalCirculation Journal
Volume76
Issue number6
DOIs
Publication statusPublished - Jun 2012

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Matsumura, K., Arima, H., Tominaga, M., Ohtsubo, T., Sasaguri, T., Fujii, K., Fukuhara, M., Uezono, K., Morinaga, Y., Ohta, Y., Otonari, T., Kawasaki, J., Kato, I., & Tsuchihashi, T. (2012). Does a combination pill of antihypertensive drugs improve medication adherence in Japanese?-a randomized controlled trial. Circulation Journal, 76(6), 1415-1422. https://doi.org/10.1253/circj.CJ-11-1481