Does apparent diffusion coefficient predict the degree of liver regeneration of donor and recipient after living donor liver transplantation?

Koichiro Morita, Akihiro Nishie, Yoshiki Asayama, Kosei Ishigami, yasuhiro ushijima, Yukihisa Takayama, daisuke okamoto, nobuhiro fujita, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Objective To elucidate the relationship between the ADCs of the liver graft and the remnant liver and the degree of liver regeneration in LDLT. Materials and methods 15 recipients and 15 corresponding donors underwent magnetic resonance imaging and computed tomography 1–2 weeks after living donor liver transplantation (LDLT). For diffusion-weighted imaging (DWI), a single-shot echo-planar sequence with b-factors of 0, 500, and 1000 s/mm2 was scanned. ADCs of the liver parenchyma were calculated at b factors of 0 and 500 and 1000 (ADC 0–500–1000) or 0 and 500 (ADC 0–500) or 500 and 1000 (ADC 500–1000). The liver volume ratio at LDLT, the mean ADCs and the regeneration rate were compared between the graft and the remnant liver using paired-t tests. Results The mean liver volume ratio of the recipients (41.3 ± 9.8%) tended to be smaller than that of the donors (51.8 ± 13.8%). The mean ADC 0–500 of the remnant liver (1.72 ± 0.33) was significantly higher than that of the graft (1.43 ± 0.32). The regeneration rate of the graft (2.07 ± 0.41) was significantly higher than that of the remnant liver (1.53 ± 0.49). Conclusion ADC 0–500 can describe differences in blood perfusion between liver grafts and the remnant liver according to the degree of liver regeneration.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalEuropean Journal of Radiology
Volume90
DOIs
Publication statusPublished - May 1 2017

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Liver Regeneration
Living Donors
Liver Transplantation
Tissue Donors
Liver
Transplants
Regeneration
Perfusion
Tomography
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Does apparent diffusion coefficient predict the degree of liver regeneration of donor and recipient after living donor liver transplantation? / Morita, Koichiro; Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kosei; ushijima, yasuhiro; Takayama, Yukihisa; okamoto, daisuke; fujita, nobuhiro; Ikegami, Toru; Yoshizumi, Tomoharu; Shirabe, Ken; Honda, Hiroshi.

In: European Journal of Radiology, Vol. 90, 01.05.2017, p. 146-151.

Research output: Contribution to journalArticle

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author = "Koichiro Morita and Akihiro Nishie and Yoshiki Asayama and Kosei Ishigami and yasuhiro ushijima and Yukihisa Takayama and daisuke okamoto and nobuhiro fujita and Toru Ikegami and Tomoharu Yoshizumi and Ken Shirabe and Hiroshi Honda",
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AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - ushijima, yasuhiro

AU - Takayama, Yukihisa

AU - okamoto, daisuke

AU - fujita, nobuhiro

AU - Ikegami, Toru

AU - Yoshizumi, Tomoharu

AU - Shirabe, Ken

AU - Honda, Hiroshi

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AB - Objective To elucidate the relationship between the ADCs of the liver graft and the remnant liver and the degree of liver regeneration in LDLT. Materials and methods 15 recipients and 15 corresponding donors underwent magnetic resonance imaging and computed tomography 1–2 weeks after living donor liver transplantation (LDLT). For diffusion-weighted imaging (DWI), a single-shot echo-planar sequence with b-factors of 0, 500, and 1000 s/mm2 was scanned. ADCs of the liver parenchyma were calculated at b factors of 0 and 500 and 1000 (ADC 0–500–1000) or 0 and 500 (ADC 0–500) or 500 and 1000 (ADC 500–1000). The liver volume ratio at LDLT, the mean ADCs and the regeneration rate were compared between the graft and the remnant liver using paired-t tests. Results The mean liver volume ratio of the recipients (41.3 ± 9.8%) tended to be smaller than that of the donors (51.8 ± 13.8%). The mean ADC 0–500 of the remnant liver (1.72 ± 0.33) was significantly higher than that of the graft (1.43 ± 0.32). The regeneration rate of the graft (2.07 ± 0.41) was significantly higher than that of the remnant liver (1.53 ± 0.49). Conclusion ADC 0–500 can describe differences in blood perfusion between liver grafts and the remnant liver according to the degree of liver regeneration.

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