Does Cob(II)alamin act as a conductor in coenzyme B12 dependent mutases?

Pawel M. Kozlowski, Takashi Kamachi, Tetsuo Toraya, Kazunari Yoshizawa

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To conduct a concert of Co-C bond cleavage and subsequent H-atom abstraction may be the role of cob(II)alamin in coenzyme B12 dependent mutases (see picture, Ado = adenosyl). Evidence is presented on the basis of DFT analysis that these reactions are concerted and that the radicals generated during the catalytic process are stabilized by the presence of corrin. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)980-983
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number6
DOIs
Publication statusPublished - Feb 7 2007

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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