Does decreased diastolic blood pressure associate with increased mortality in 80-year-old japanese

Shuntaro Kagiyama, Yutaka Takata, Toshihiro Ansai, Kiyoshi Matsumura, Inho Soh, Shuji Awano, Kazuo Sonoki, Akihiro Yoshida, Takehiro Torisu, Tomoko Hamasaki, Ikuo Nakamichi, Tadamichi Takehara, Mitsuo Iida

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Hypertension is one of the greatest risk factors for cardiovascular disease, but its contribution to cardiovascular mortality weakens with aging. We have previously demonstrated that at the age of 80, higher systolic blood pressure (SBP) is not correlated with increased mortality in Japan. However, we did not examine in detail whether diastolic blood pressure (DBP) independently affects mortality. In the present study, 639 participants, who were 80 years old in 1997, were enrolled. The subjects were divided by their DBP [below 70 mmHg (group 1, n = 136), from 70 mmHg to 80 mmHg (group 2, n = 200), from 80 mmHg to 90 mmHg (group 3, n = 194), over 90 mmHg (group 4, n = 109)]. During the 4-year follow-up period, 90 individuals died. Cox multivariate regression analysis revealed that group 1 showed a significantly higher mortality rate than group 4 [relative risk (RR) 2.47, confidence interval (CI) 1.0-75.70, p = 0.03)]. The relative risks of deaths from cardiovascular diseases, pneumonia, and cancer tended to be higher in group 1 than in group 4, but the difference did not reach statistical significance. These results suggest that decreased DBP is associated with higher mortality in the Japanese elderly.

    Original languageEnglish
    Pages (from-to)639-647
    Number of pages9
    JournalClinical and Experimental Hypertension
    Volume31
    Issue number8
    DOIs
    Publication statusPublished - Dec 2009

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Physiology

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