Does the deletion within T cell receptor β‐chain gene of NZW mice contribute to autoimmunity in (NZB × NZW)F1mice?

Yusuke Yanagi, Sachiko Hirose, Ryuji Nagasawa, Toshikazu Shirai, Tak W. Mak, Tomio Tada

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To determine the transacting genetic factors of NZW contributing to the development of autoimmune disease in (NZB ± NZW)F1 (B/WF1) mice, we examined the relationship between the T cell receptor β chain gene deletion and the severity of autoimmune manifestations in 76 B/WF1 ± NZB backcross mice. Very high association between the T cell receptor β chain gene deletion and the development of autoimmune manifestations including the production of IgG anti‐DNA antibodies and circulating retroviral gp70 immune complexes was observed, indicating that a defect in the NZW T cell receptor β chain gene or a locus closely linked to it contributes to the autoantibody formation in B/WF1.

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalEuropean Journal of Immunology
Volume16
Issue number9
DOIs
Publication statusPublished - Jan 1 1986
Externally publishedYes

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T-Cell Receptor Genes
Autoimmunity
Gene Deletion
Inbred NZB Mouse
Antigen-Antibody Complex
Autoantibodies
Autoimmune Diseases
Immunoglobulin G
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Does the deletion within T cell receptor β‐chain gene of NZW mice contribute to autoimmunity in (NZB × NZW)F1mice? / Yanagi, Yusuke; Hirose, Sachiko; Nagasawa, Ryuji; Shirai, Toshikazu; Mak, Tak W.; Tada, Tomio.

In: European Journal of Immunology, Vol. 16, No. 9, 01.01.1986, p. 1179-1182.

Research output: Contribution to journalArticle

Yanagi, Yusuke ; Hirose, Sachiko ; Nagasawa, Ryuji ; Shirai, Toshikazu ; Mak, Tak W. ; Tada, Tomio. / Does the deletion within T cell receptor β‐chain gene of NZW mice contribute to autoimmunity in (NZB × NZW)F1mice?. In: European Journal of Immunology. 1986 ; Vol. 16, No. 9. pp. 1179-1182.
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