Dominant expression of interleukin 10 but not interferon γ in CD4-CD8- αβT cells of autoimmune lymphoproliferative syndrome

Shouichi Ohga, Akihiko Nomura, Yasushi Takahata, Kenji Ihara, Hidetoshi Takada, Hiroshi Wakiguchi, Yuji Kudo, Toshiro Hara

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cytokine expression in CD4-CD8- double-negative (DN) T cells of autoimmune lymphoproliferative syndrome (ALPS) was analysed. Two patients with DN αβT-cell expansion showed higher serum interleukin 10 (IL-10) levels than one patient without it. Intracellular flow-cytometric analysis indicated the IL-10-expressing CD3+CD4-CD8- cells in patients with lymphoproliferation. Quantitative real-time polymerase chain reaction revealed ∼100 times higher IL-10, but not interferon-γ or transforming growth factor-β in DN than in single-positive T cells. IL-10 was exclusively expressed in DN αβ but not γδT cells. Circulating DN αβT cells may constitutively express IL-10 and contribute to the ALPS phenotype.

Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalBritish Journal of Haematology
Volume119
Issue number2
DOIs
Publication statusPublished - Dec 2 2002

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Autoimmune Lymphoproliferative Syndrome
Interleukin-10
Interferons
T-Lymphocytes
Transforming Growth Factors
Real-Time Polymerase Chain Reaction
Cytokines
Phenotype
Serum

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Dominant expression of interleukin 10 but not interferon γ in CD4-CD8- αβT cells of autoimmune lymphoproliferative syndrome. / Ohga, Shouichi; Nomura, Akihiko; Takahata, Yasushi; Ihara, Kenji; Takada, Hidetoshi; Wakiguchi, Hiroshi; Kudo, Yuji; Hara, Toshiro.

In: British Journal of Haematology, Vol. 119, No. 2, 02.12.2002, p. 535-538.

Research output: Contribution to journalArticle

Ohga, Shouichi ; Nomura, Akihiko ; Takahata, Yasushi ; Ihara, Kenji ; Takada, Hidetoshi ; Wakiguchi, Hiroshi ; Kudo, Yuji ; Hara, Toshiro. / Dominant expression of interleukin 10 but not interferon γ in CD4-CD8- αβT cells of autoimmune lymphoproliferative syndrome. In: British Journal of Haematology. 2002 ; Vol. 119, No. 2. pp. 535-538.
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AU - Ihara, Kenji

AU - Takada, Hidetoshi

AU - Wakiguchi, Hiroshi

AU - Kudo, Yuji

AU - Hara, Toshiro

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