Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

Takehiro Kawashiri, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalJournal of Pharmacological Sciences
Volume140
Issue number3
DOIs
Publication statusPublished - Jul 2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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