Donor risk in adult-to-adult living donor liver transplantation: Impact of left lobe graft

Akinobu Taketomi, Hiroto Kayashima, Yuji Soejima, Tomoharu Yoshizumi, Hideaki Uchiyama, Toru Ikegami, Yoichi Yamashita, Noboru Harada, Mitsuo Shimada, Yoshihiko Maehara

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Abstract

Background.: To ensure donor safety in adult-to-adult living donor liver transplantation, we established a selection criterion for donors in which left lobe (LL) was the first choice of graft. Methods.: Two hundred six consecutive donors were retrospectively studied. Donors were divided into two groups according to graft type: LL graft (n=137) and right lobe (RL) graft (n=69). Results.: Although mean intraoperative blood loss of LL was significantly increased compared with RL, mean peak postoperative total bilirubin levels and duration of hospital stay after surgery were significantly less for LL than RL (P<0.05). No donor died or suffered a life-threatening complication during the study period. The overall complication rate was 34.0%, including biliary complications in 5.3%. The number of biliary complications was four (2.9%) in LL and seven (10.1%) in RL (P<0.05). Logistic regression analysis revealed that only graft type (LL vs. RL) is significantly related to the occurrence of biliary complications (odds ratio 0.11; P=0.0012). The cumulative overall graft survival rates in the recipients with LL were not significantly different from that in the recipients with RL. Conclusions.: LL grafting should be considered favorably when selecting donors for adult-to-adult living donor liver transplantation.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalTransplantation
Volume87
Issue number3
DOIs
Publication statusPublished - Feb 15 2009

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Living Donors
Liver Transplantation
Tissue Donors
Transplants
Graft Survival
Bilirubin
Patient Selection
Length of Stay
Logistic Models
Odds Ratio
Regression Analysis
Safety

All Science Journal Classification (ASJC) codes

  • Transplantation

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Donor risk in adult-to-adult living donor liver transplantation : Impact of left lobe graft. / Taketomi, Akinobu; Kayashima, Hiroto; Soejima, Yuji; Yoshizumi, Tomoharu; Uchiyama, Hideaki; Ikegami, Toru; Yamashita, Yoichi; Harada, Noboru; Shimada, Mitsuo; Maehara, Yoshihiko.

In: Transplantation, Vol. 87, No. 3, 15.02.2009, p. 445-450.

Research output: Contribution to journalArticle

Taketomi, Akinobu ; Kayashima, Hiroto ; Soejima, Yuji ; Yoshizumi, Tomoharu ; Uchiyama, Hideaki ; Ikegami, Toru ; Yamashita, Yoichi ; Harada, Noboru ; Shimada, Mitsuo ; Maehara, Yoshihiko. / Donor risk in adult-to-adult living donor liver transplantation : Impact of left lobe graft. In: Transplantation. 2009 ; Vol. 87, No. 3. pp. 445-450.
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