TY - JOUR
T1 - Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
AU - Tomiyama, Takahiro
AU - Harada, Noboru
AU - Toshima, Takeo
AU - Nakayama, Yuki
AU - Toshida, Katsuya
AU - Morinaga, Akinari
AU - Kosai-Fujimoto, Yukiko
AU - Tomino, Takahiro
AU - Kurihara, Takeshi
AU - takeishi, kazuki
AU - Nagao, Yoshihiro
AU - Morita, Kazutoyo
AU - Itoh, Shinji
AU - Yoshizumi, Tomoharu
N1 - Funding Information:
This study was supported by the following grants: AMED Grant Numbers JP20fk0310106h204 and JP20fk0210035s0503 and JSPS KAKENHI Grant Number JP18K08542. The funding sources had no role in collection, analysis or interpretation of data, or in the decision to submit the article for publication.
Publisher Copyright:
Copyright © 2022 Tomiyama, Harada, Toshima, Nakayama, Toshida, Morinaga, Kosai-Fujimoto, Tomino, Kurihara, Takeishi, Nagao, Morita, Itoh and Yoshizumi.
PY - 2022/12/9
Y1 - 2022/12/9
N2 - The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients.
AB - The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients.
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U2 - 10.3389/ti.2022.10723
DO - 10.3389/ti.2022.10723
M3 - Article
C2 - 36568139
AN - SCOPUS:85144638044
SN - 0934-0874
VL - 35
JO - Transplant International
JF - Transplant International
M1 - 10723
ER -