Dopamine receptor agonists and antagonists enhance ATP-activated currents

Kazuhide Inoue, Ken Nakazawa, Tomokazu Watano, Mica Ohara-Imaizumi, Kannosuke Fujimori, Akira Takanaka

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Abstract

The effects of dopamine and related compounds on ATP-activated channels were investigated in pheochromocytoma PC12 cells. Dopamine (10 μM) enhanced an inward current activated by 100 μM ATP. A similar enhancement of the ATP-activated current was observed with apomorphine (10 μM), a non-selective dopamine receptor agonist, with (+)-SKF-38393 (10 μM), a selective dopamine D1 receptor agonist, and with (-)-quinpirole (10 μM), a selective dopamine D2 receptor agonist. Moreover, (+)-SCH-23390 (30 μM), a dopamine D1 receptor antagonist, and (-)-sulpiride (30 μM), a dopamine D2 receptor antagonist, also enhanced the ATP-activated current. The results suggest that ATP-activated channels are modulated by dopaminergic mechanisms, and that this modulation cannot be attributed to any single class of dopamine receptors.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
Publication statusPublished - May 14 1992
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Inoue, K., Nakazawa, K., Watano, T., Ohara-Imaizumi, M., Fujimori, K., & Takanaka, A. (1992). Dopamine receptor agonists and antagonists enhance ATP-activated currents. European Journal of Pharmacology, 215(2-3), 321-324. https://doi.org/10.1016/0014-2999(92)90049-A