Dorisenones, cytotoxic spongian diterpenoids, from the nudibranch Chromodoris obsoleta

Tomofumi Miyamoto, Kenichiro Sakamoto, Kazuyoshi Arao, Tetsuya Komori, Ryuichi Higuchi, Takuma Sasaki

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35 Citations (Scopus)

Abstract

Seven new cytotoxic spongian diterpenoids, dorisenones A (1), B (2), C (3), D (4), 7α-hydroxyspongian-16-one (5), 15α, 16α-diacetoxy-11, 12β- epoxyspongian (6) and 7α-acetoxydendrillol-3 (7) were isolated from a Japanese marine mollusk Chromodoris obsoleta (Chromodorididae), together with four known spongian diterpenoids. Their structures have been elucidated by spectroscopic evidence and single crystal X ray analysis.

Original languageEnglish
Pages (from-to)8187-8198
Number of pages12
JournalTetrahedron
Volume52
Issue number24
DOIs
Publication statusPublished - Jun 10 1996

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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