Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development

nobuhiro fujita, Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Hidetaka Yamamoto, Akinobu Taketomi, Yoshinao Oda, Hiroshi Honda, Masazumi Tsuneyoshi

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Abstract

Hepatocellular carcinoma develops in a multistep process. Previous studies have revealed changes in blood supply in hepatocellular carcinoma during its carcinogenesis. However, little is known about the relationship between tumor vasculature and the biological behavior of moderately differentiated hepatocellular carcinoma which demonstrates varied degrees of biological behavior. We immunohistochemically assessed intratumoral arterial vessel density (by high-molecular-weight caldesmon and calponin) and microvessel density (by CD34) in 123 cases of moderately differentiated hepatocellular carcinomas, and compared these densities with clinicopathological findings. Arterial vessel density and microvessel density of 19 well-differentiated and 37 poorly differentiated hepatocellular carcinomas were also evaluated. The arterial vessel density of moderately differentiated hepatocellular carcinomas with capsule formation, infiltration to the capsule, portal venous invasion, and high Ki-67 labeling index was lower than that of moderately differentiated hepatocellular carcinomas without these pathological findings (high-molecular-weight caldesmon: P < .0001, P = .0074, P = .0009, P = .0244, calponin: P < .0001, P = .0695, P = .0033, and P = .0155, respectively). The low arterial vessel density group (<10) of moderately differentiated hepatocellular carcinomas tended to show poorer overall survival than the high arterial vessel density group (≥10) (high-molecular-weight caldesmon: P = .0347, calponin: P = .0404). The arterial vessel density and microvessel density of moderately differentiated hepatocellular carcinomas were significantly higher than those of well-differentiated hepatocellular carcinomas (high-molecular-weight caldesmon: P = .022, calponin: P = .027, CD34: P = .036) and poorly differentiated hepatocellular carcinomas (high-molecular-weight caldesmon, calponin and CD34: P < .0001). The moderately differentiated hepatocellular carcinomas with lower arterial vessel density had more malignant potential than those with higher arterial vessel density. The changes of arterial vessel density in moderately differentiated hepatocellular carcinomas were suggested.

Original languageEnglish
Pages (from-to)838-847
Number of pages10
JournalHuman Pathology
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 1 2010

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Hepatocellular Carcinoma
Down-Regulation
Arteries
Calmodulin-Binding Proteins
Neoplasms
Molecular Weight
Microvessels
Capsules
Carcinogenesis
calponin

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development. / fujita, nobuhiro; Aishima, Shinichi; Iguchi, Tomohiro; Nishihara, Yunosuke; Yamamoto, Hidetaka; Taketomi, Akinobu; Oda, Yoshinao; Honda, Hiroshi; Tsuneyoshi, Masazumi.

In: Human Pathology, Vol. 41, No. 6, 01.06.2010, p. 838-847.

Research output: Contribution to journalArticle

fujita, N, Aishima, S, Iguchi, T, Nishihara, Y, Yamamoto, H, Taketomi, A, Oda, Y, Honda, H & Tsuneyoshi, M 2010, 'Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development', Human Pathology, vol. 41, no. 6, pp. 838-847. https://doi.org/10.1016/j.humpath.2009.11.011
fujita, nobuhiro ; Aishima, Shinichi ; Iguchi, Tomohiro ; Nishihara, Yunosuke ; Yamamoto, Hidetaka ; Taketomi, Akinobu ; Oda, Yoshinao ; Honda, Hiroshi ; Tsuneyoshi, Masazumi. / Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development. In: Human Pathology. 2010 ; Vol. 41, No. 6. pp. 838-847.
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AU - Tsuneyoshi, Masazumi

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