Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells

Masato Ikeda, Isamu Okamoto, Kenji Tamura, Taroh Satoh, Kimio Yonesaka, Masahiro Fukuoka, Kazuhiko Nakagawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Deregulation of survivin expression is implicated in tumorigenesis. To examine the regulation of survivin expression in response to DNA damage, we exposed A549 human lung cancer cells to ultraviolet C (UVC) radiation, which induces DNA single-strand breakage. UVC irradiation induced G2-M arrest that was accompanied by accumulation of p53 and subsequent down-regulation of survivin. Depletion of p53 by RNA interference prevented the UVC-induced down-regulation of survivin. Furthermore, depletion of survivin resulted in G2-M arrest, suggesting that down-regulation of survivin by p53 contributes to the p53-dependent G2-M checkpoint triggered by DNA damage.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalCancer Letters
Volume248
Issue number2
DOIs
Publication statusPublished - Apr 18 2007
Externally publishedYes

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Down-Regulation
Radiation
DNA Damage
RNA Interference
Lung Neoplasms
Carcinogenesis
DNA
A549 Cells

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells. / Ikeda, Masato; Okamoto, Isamu; Tamura, Kenji; Satoh, Taroh; Yonesaka, Kimio; Fukuoka, Masahiro; Nakagawa, Kazuhiko.

In: Cancer Letters, Vol. 248, No. 2, 18.04.2007, p. 292-298.

Research output: Contribution to journalArticle

Ikeda, Masato ; Okamoto, Isamu ; Tamura, Kenji ; Satoh, Taroh ; Yonesaka, Kimio ; Fukuoka, Masahiro ; Nakagawa, Kazuhiko. / Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells. In: Cancer Letters. 2007 ; Vol. 248, No. 2. pp. 292-298.
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