Downregulation of CXCR5 in CD27- B cells of HIV-1 infected patients

Yong Chong, Shigeki Nabeshima, Norihiro Furusyo, Masayuki Murata, Kouzaburo Yamaji, Jun Hayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The CD27- (naive) B cells of HIV-1 infected patients have been shown to be increased in frequency and to be activated, as indicated by high CD38 expression on the cell surface. CXCR5, a B cell chemokine receptor, is expressed on circulating CD27- (naive) B cells and plays a pivotal role in peripheral B cell development. To investigate the effect of HIV-1 infection on the expression of this chemokine receptor on naive B cells, the expression level of CXCR5 on CD27- B cells was examined in 19 drug-naive HIV-1 infected patients, 27 HAART-treated patients, and 20 controls. CXCR5 expression on CD27- B cells was significantly lower in drug-naive patients than in HAART-treated patients and controls (P<0.01). CD27- B cells with high CD38 expression exhibited low CXCR5 expression. The CXCR5 expression level on CD27- B cells recovered to within the normal range after effective antiretroviral therapy. These findings suggested that HIV-1 infection induces a remarkable phenotypic alteration of naive B cells and that the activated naive B cells found in HIV-1 infection down-regulate CXCR5 on their surface. Impaired homing of naive B cells may contribute to HIV-1 induced immunological deficiencies.

Original languageEnglish
Pages (from-to)362-367
Number of pages6
JournalJournal of Medical Virology
Volume73
Issue number3
DOIs
Publication statusPublished - Jul 1 2004

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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