Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice

Masaki Fujita, Qing Ye, Hiroshi Ouchi, Eiji Harada, Ichiro Inoshima, Kazuyoshi Kuwano, Yoichi Nakanishi

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number2
DOIs
Publication statusPublished - Feb 2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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