Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice

Masaki Fujita, Qing Ye, Hiroshi Ouchi, Eiji Harada, Ichiro Inoshima, Kazuyoshi Kuwano, Yoichi Nakanishi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number2
DOIs
Publication statusPublished - Feb 1 2006

Fingerprint

Pulmonary Fibrosis
Doxycycline
Gelatinases
Neutrophils
Fibrosis
indium-bleomycin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice. / Fujita, Masaki; Ye, Qing; Ouchi, Hiroshi; Harada, Eiji; Inoshima, Ichiro; Kuwano, Kazuyoshi; Nakanishi, Yoichi.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 2, 01.02.2006, p. 739-743.

Research output: Contribution to journalArticle

Fujita, Masaki ; Ye, Qing ; Ouchi, Hiroshi ; Harada, Eiji ; Inoshima, Ichiro ; Kuwano, Kazuyoshi ; Nakanishi, Yoichi. / Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice. In: Antimicrobial Agents and Chemotherapy. 2006 ; Vol. 50, No. 2. pp. 739-743.
@article{9d34767b8f964cc3a80bcdb0ede721a1,
title = "Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice",
abstract = "The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.",
author = "Masaki Fujita and Qing Ye and Hiroshi Ouchi and Eiji Harada and Ichiro Inoshima and Kazuyoshi Kuwano and Yoichi Nakanishi",
year = "2006",
month = "2",
day = "1",
doi = "10.1128/AAC.50.2.739-743.2006",
language = "English",
volume = "50",
pages = "739--743",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice

AU - Fujita, Masaki

AU - Ye, Qing

AU - Ouchi, Hiroshi

AU - Harada, Eiji

AU - Inoshima, Ichiro

AU - Kuwano, Kazuyoshi

AU - Nakanishi, Yoichi

PY - 2006/2/1

Y1 - 2006/2/1

N2 - The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

AB - The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

UR - http://www.scopus.com/inward/record.url?scp=31944448350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31944448350&partnerID=8YFLogxK

U2 - 10.1128/AAC.50.2.739-743.2006

DO - 10.1128/AAC.50.2.739-743.2006

M3 - Article

C2 - 16436734

AN - SCOPUS:31944448350

VL - 50

SP - 739

EP - 743

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 2

ER -