TY - JOUR
T1 - Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice
AU - Fujita, Masaki
AU - Ye, Qing
AU - Ouchi, Hiroshi
AU - Harada, Eiji
AU - Inoshima, Ichiro
AU - Kuwano, Kazuyoshi
AU - Nakanishi, Yoichi
PY - 2006/2
Y1 - 2006/2
N2 - The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
AB - The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
UR - http://www.scopus.com/inward/record.url?scp=31944448350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31944448350&partnerID=8YFLogxK
U2 - 10.1128/AAC.50.2.739-743.2006
DO - 10.1128/AAC.50.2.739-743.2006
M3 - Article
C2 - 16436734
AN - SCOPUS:31944448350
SN - 0066-4804
VL - 50
SP - 739
EP - 743
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
