TY - JOUR
T1 - Drainage Retinotomy Confers Risk of Epiretinal Membrane Formation After Vitrectomy for Rhegmatogenous Retinal Detachment Repair
AU - Ishikawa, Keijiro
AU - Akiyama, Masato
AU - Mori, Kenichiro
AU - Nakama, Takahito
AU - Notomi, Shoji
AU - Nakao, Shintaro
AU - Kohno, Ri ichiro
AU - Takeda, Atsunobu
AU - Sonoda, Koh Hei
N1 - Funding Information:
We thank Editage for English language editing and the institutions of the Japan-Retinal Detachment Registry project committee (1-4 below) and their collaborators (5-26 below): 1) Chiba University: Shuichi Yamamoto, Takayuki Baba, Eiju Sato, Masayasu Kitahashi, Tomoaki Tatsumi, Gen Miura, and Tomohiro Niizawa; 2) Kagoshima University: Taiji Sakamoto, Keita Yamakiri, Toshifumi Yamashita, Hiroki Otsuka, Seiji Sameshima, Narimasa Yoshinaga, and Shozo Sonoda; 3) Kyorin University: Akito Hirakata, Takashi Koto, Makoto Inoue, Kazunari Hirota, Yuji Itoh, Tadashi Orihara, Yoshinobu Emoto, Masahiko Sano, Hiroyuki Takahashi, and Ryo Tokizawa; and 4) Yamagata University: Hidetoshi Yamashita, Koichi Nishitsuka, Yutaka Kaneko, and Katsuhiro Nishi. Collaborators include 5) Asahikawa Medical University Hospital: Akitoshi Yoshida, Shinji Ono, Hiroyuki Hirokawa, Kenji Sogawa, Tsuneaki Omae, and Akihiro Ishibazawa; 6) Gunma University: Shoji Kishi, Hideo Akiyama, Hidetaka Matsumoto, Ryo Mukai, and Masahiro Morimoto; 7) Hirosaki University: Mitsuru Nakazawa, Yukihiko Suzuki, Takashi Kudo, and Kobu Adachi; 8) Hokkaido University: Susumu Ishida, Kousuke Noda, Satoru Kase, Syouhei Mori, Ryo Ando, Michiyuki Saito, and Tomohiro Suzuki; 9) Kansai Medical University Hospital: Kanji Takahashi, Yoshimi Nagai, Tadashi Nakauchi, and Haruiko Yamada; 10) Kindai University Sakai Hospital: Shuji Kusaka and Daishi Tsujioka; 11) Kyoto University: Akitaka Tsujikawa and Kiyoshi Suzuma; 12) Kyushu University: Tatsuro Ishibashi, Koh-Hei Sonoda, Yasuhiro Ikeda, Riichiro Kohno, and Keijiro Ishikawa; 12) Mie University: Mineo Kondo and Maki Kozawa; 14) Nagasaki University: Takashi Kitaoka and Eiko Tsuiki; 15) Nagoya City University: Yuichiro Ogura, Munenori Yoshida, Hiroshi Morita, Aki Kato, Yoshio Hirano, and Kazuhiko Sugitani; 16) Nagoya University: Hiroko Terasaki, Takeshi Iwase, Yasuki Ito, Shinji Ueno, Hiroki Kaneko, Norie Nonobe, and Taro Kominami; 17) National Center for Child Health and Development: Noriyuki Azuma and Tadashi Yokoi; 18) Nihon University Hospital: Hiroyuki Shimada, Hiroyuki Nakashizuka, Takayuki Hattori, Ari Shinojima, and Yorihisa Kutagawa; 19) Okayama University: Fumio Shiraga, Yuki Morizane, and Shuhei Kimura; 20) Osaka Medical School: Tsunehiko Ikeda, Teruyo Kida, Takaki Sato, and Masanori Fukumoto; 21) Osaka Rosai Hospital: Kazuyuki Emi and Hiroshi Nakashima; 22) Shiga Medical University: Masahito Ohji, Masashi Kakinoki, and Osamu Sawada; 23) Takeuchi Eye Clinic: Shinobu Takeuchi and Sumiyoshi Tanaka; 24) Tokyo Women's Medical College: Tomohiro Iida, Hideki Koizumi, Ichiro Maruko, Taiji Hasegawa, and Akiko Kogure; 25) Yamanashi University: Hiroyuki Iijima, Tomohiro Oshiro, Yasushi Tateno, Wataru Kikushima, Atsushi Sugiyama, and Seigo Yoneyama; and 26) Yokohama City University Medical Center: Kazuaki Kadonosono, Shimpei Sato, and Shin Yamane.
Funding Information:
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Funding/Support: Supported by Grants-in-Aid for Scientific Research from KAKENHI (#JP20K09828), Fund for Ophthalmic Research in Commemoration of Santen Pharmaceutical's Founder, the Bayer Retina Award Foundation, and the ROHTO Award (to K.I.). Financial Disclosures: M.A. has received financial support from Nidek Co. Ltd., and K-H.S. has received financial support from Hoya Co. Ltd. and Santen Pharmaceutical Co. Ltd. The other authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/2
Y1 - 2022/2
N2 - Purpose: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Design: Nationwide, multicenter, clinical cohort study based on registry data. Methods: We reviewed 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017. Associations of 13 baseline characteristics and 8 surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score–matched analysis for the significantly associated clinical factor(s). The primary outcome measure was ERM formation after 6 months of vitrectomy. Results: ERM had developed in 104 cases (4.6%) by 6 months. We found that drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] 2.22 [95% confidence interval {CI} 1.50-3.31]; P < .001). In the propensity score–matched analysis (n = 492 in each group), we confirmed a significant difference in the incidence of ERM after 6 months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR 3.35 [95% CI 1.77-6.33]; P < .001). Conclusions: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.
AB - Purpose: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Design: Nationwide, multicenter, clinical cohort study based on registry data. Methods: We reviewed 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017. Associations of 13 baseline characteristics and 8 surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score–matched analysis for the significantly associated clinical factor(s). The primary outcome measure was ERM formation after 6 months of vitrectomy. Results: ERM had developed in 104 cases (4.6%) by 6 months. We found that drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] 2.22 [95% confidence interval {CI} 1.50-3.31]; P < .001). In the propensity score–matched analysis (n = 492 in each group), we confirmed a significant difference in the incidence of ERM after 6 months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR 3.35 [95% CI 1.77-6.33]; P < .001). Conclusions: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.
UR - http://www.scopus.com/inward/record.url?scp=85118943585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118943585&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2021.07.028
DO - 10.1016/j.ajo.2021.07.028
M3 - Article
C2 - 34339662
AN - SCOPUS:85118943585
VL - 234
SP - 20
EP - 27
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -