TY - JOUR
T1 - Draxin, a repulsive guidance protein for spinal cord and forebrain commissures
AU - Islam, Shahidul M.
AU - Shinmyo, Yohei
AU - Okafuji, Tatsuya
AU - Su, Yuhong
AU - Naser, Iftekhar Bin
AU - Ahmed, Giasuddin
AU - Zhang, Sanbing
AU - Chen, Sandy
AU - Ohta, Kunimasa
AU - Kiyonari, Hiroshi
AU - Abe, Takaya
AU - Tanaka, Satomi
AU - Nishinakamura, Ryuichi
AU - Terashima, Toshio
AU - Kitamura, Toshio
AU - Tanaka, Hideaki
PY - 2009/1/16
Y1 - 2009/1/16
N2 - Axon guidance proteins are critical for the correct wiring of the nervous system during development. Several axon guidance cues and their family members have been well characterized. More unidentified axon guidance cues are assumed to participate in the formation of the extremely complex nervous system. We identified a secreted protein, draxin, that shares no homology with known guidance cues. Draxin inhibited or repelled neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Ectopically expressed draxin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo. draxin knockout mice showed defasciculation of spinal cord commissural axons and absence of all forebrain commissures. Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures.
AB - Axon guidance proteins are critical for the correct wiring of the nervous system during development. Several axon guidance cues and their family members have been well characterized. More unidentified axon guidance cues are assumed to participate in the formation of the extremely complex nervous system. We identified a secreted protein, draxin, that shares no homology with known guidance cues. Draxin inhibited or repelled neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Ectopically expressed draxin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo. draxin knockout mice showed defasciculation of spinal cord commissural axons and absence of all forebrain commissures. Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures.
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U2 - 10.1126/science.1165187
DO - 10.1126/science.1165187
M3 - Article
C2 - 19150847
AN - SCOPUS:58449090394
VL - 323
SP - 388
EP - 393
JO - Science
JF - Science
SN - 0036-8075
IS - 5912
ER -