Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist

Kyoko Fukunaga, Takahiro Tsukida, Hideki Moriyama, Hirosato Kondo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have designed a series of simple rigid compounds (2) having a phenyl ring attached to three essential groups necessary for selectin binding, i.e., a fucose unit, a carboxylic acid, and the hydrophobic part. In this series of compound 2, 2a exhibited strong inhibitory activity in in vitro P-selectin mediated cell adhesion assay. The novel type of compound 2a would be a potential lead compound for selectin antagonist.

Original languageEnglish
Pages (from-to)2365-2367
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number17
DOIs
Publication statusPublished - Sep 3 2001
Externally publishedYes

Fingerprint

Selectins
Drug Evaluation
Drug Design
Lead compounds
P-Selectin
Fucose
Cell adhesion
Carboxylic Acids
Cell Adhesion
Pharmaceutical Preparations
Assays
Lead
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist. / Fukunaga, Kyoko; Tsukida, Takahiro; Moriyama, Hideki; Kondo, Hirosato.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 17, 03.09.2001, p. 2365-2367.

Research output: Contribution to journalArticle

Fukunaga, Kyoko ; Tsukida, Takahiro ; Moriyama, Hideki ; Kondo, Hirosato. / Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 17. pp. 2365-2367.
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