Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Minghui Zan; Junjie Li; Shizhong Luo; Zhishen Ge

doi:10.1039/c4cc03120b

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Minghui Zan, Junjie Li, Shizhong Luo, Zhishen Ge

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Original language	English
Pages (from-to)	7824-7827
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	58
DOIs	https://doi.org/10.1039/c4cc03120b
Publication status	Published - Jun 24 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc03120b

Cite this

@article{4ff5b37360e04856a89766c80b1d3cc4,

title = "Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels",

abstract = "The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.",

author = "Minghui Zan and Junjie Li and Shizhong Luo and Zhishen Ge",

year = "2014",

month = jun,

day = "24",

doi = "10.1039/c4cc03120b",

language = "English",

volume = "50",

pages = "7824--7827",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "58",

}

TY - JOUR

T1 - Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

AU - Zan, Minghui

AU - Li, Junjie

AU - Luo, Shizhong

AU - Ge, Zhishen

PY - 2014/6/24

Y1 - 2014/6/24

N2 - The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

AB - The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

UR - http://www.scopus.com/inward/record.url?scp=84903134069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903134069&partnerID=8YFLogxK

U2 - 10.1039/c4cc03120b

DO - 10.1039/c4cc03120b

M3 - Article

C2 - 24909859

AN - SCOPUS:84903134069

VL - 50

SP - 7824

EP - 7827

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 58

ER -

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this