Dual Si-H effects in platinum-catalyzed silane reduction of carboxamides leading to a practical synthetic process of tertiary-amines involving self-encapsulation of the catalyst species into the insoluble silicone resin formed

Shiori Hanada, Yukihiro Motoyama, Hideo Nagashima

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Combination of commercially available platinum catalysts with siloxanes containing more than two Si-H groups is found to be an efficient catalyst system for the reduction of carboxamides to amines. In particular, facile removal of silicon and platinum residues from the product can be achieved by the use of polymethylhydrosiloxanes as reducing reagents.

Original languageEnglish
Pages (from-to)6173-6177
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number35
DOIs
Publication statusPublished - Aug 28 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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