Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats

Tomoko Fujise, Toshiro Matsui, Kiyoshi Matsumoto, Norihiko Terahara, Keiichi Fukui, Koichi Sugita, Tomoko Fujise, Hideaki Ohta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.

Original languageEnglish
Pages (from-to)477-484
Number of pages8
JournalFood Science and Technology Research
Volume14
Issue number5
DOIs
Publication statusPublished - Jan 1 2008

Fingerprint

Glucosidases
glycemic effect
glucosidases
Maltose
maltose
Hypoglycemic Agents
Rats
rats
Ipomoea batatas
sweet potatoes
oral administration
blood glucose
Oral Administration
Sprague Dawley Rats
Blood Glucose
duration
6-O-caffeoyl-(2-O-glucopyranosyl)-glucopyranose
Rat
Durables
Glucose

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

Cite this

Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats. / Fujise, Tomoko; Matsui, Toshiro; Matsumoto, Kiyoshi; Terahara, Norihiko; Fukui, Keiichi; Sugita, Koichi; Fujise, Tomoko; Ohta, Hideaki.

In: Food Science and Technology Research, Vol. 14, No. 5, 01.01.2008, p. 477-484.

Research output: Contribution to journalArticle

Fujise, Tomoko ; Matsui, Toshiro ; Matsumoto, Kiyoshi ; Terahara, Norihiko ; Fukui, Keiichi ; Sugita, Koichi ; Fujise, Tomoko ; Ohta, Hideaki. / Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats. In: Food Science and Technology Research. 2008 ; Vol. 14, No. 5. pp. 477-484.
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AU - Terahara, Norihiko

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AU - Sugita, Koichi

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