Abstract
To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.
| Original language | English |
|---|---|
| Pages (from-to) | 477-484 |
| Number of pages | 8 |
| Journal | Food Science and Technology Research |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Chemical Engineering(all)
- Industrial and Manufacturing Engineering
- Marketing
Cite this
Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats. / Fujise, Tomoko; Matsui, Toshiro; Matsumoto, Kiyoshi; Terahara, Norihiko; Fukui, Keiichi; Sugita, Koichi; Fujise, Tomoko; Ohta, Hideaki.
In: Food Science and Technology Research, Vol. 14, No. 5, 01.01.2008, p. 477-484.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats
AU - Fujise, Tomoko
AU - Matsui, Toshiro
AU - Matsumoto, Kiyoshi
AU - Terahara, Norihiko
AU - Fukui, Keiichi
AU - Sugita, Koichi
AU - Fujise, Tomoko
AU - Ohta, Hideaki
PY - 2008/1/1
Y1 - 2008/1/1
N2 - To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.
AB - To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.
UR - http://www.scopus.com/inward/record.url?scp=70349366652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349366652&partnerID=8YFLogxK
U2 - 10.3136/fstr.14.477
DO - 10.3136/fstr.14.477
M3 - Article
AN - SCOPUS:70349366652
VL - 14
SP - 477
EP - 484
JO - Food Science and Technology Research
JF - Food Science and Technology Research
SN - 1344-6606
IS - 5
ER -