Abstract
Background: The inconsistency of previous reports examining cognitive function in obsessive-compulsive disorder (OCD) suggests its heterogeneity. In this study, we examined the effect of illness duration on cognitive function in OCD. Methods: We examined the cognitive function of 32 OCD patients and 16 healthy volunteers by neuropsychological tests and functional magnetic resonance imaging while they performed the Stroop and N-back tasks to assess attention and nonverbal memory. The patients were divided into two groups by illness duration: a short-term group (n=17, 5.5±3.1 years) and a long-term group (n=15, 20.3±6.1 years). Statistical analysis was performed to determine the differences between these two groups and the normal control group (n=16). Results: The long-term group showed attention deficit and nonverbal memory dysfunction on the neuropsychological tests. In contrast, on functional magnetic resonance imaging, the short-term group showed weaker activation of the right caudate during the Stroop task and stronger activation of the right dorso-lateral prefrontal cortex during the N-back task than the long-term and normal control groups. Conclusions: The results suggested that abnormal brain activation occurs in the early phase of OCD and that the long-term persistence of OCD might involve a decline in cognitive function.
| Original language | English |
|---|---|
| Pages (from-to) | 814-823 |
| Number of pages | 10 |
| Journal | Depression and Anxiety |
| Volume | 26 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2009 |
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All Science Journal Classification (ASJC) codes
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Duration effect of obsessive-compulsive disorder on cognitive function : A functional MRI study. / Nakao, Tomohiro; Nakagawa, Akiko; Yoshiura, Takashi; Nakatani, Eriko; Nabeyama, Maiko; Sanematsu, Hirokuni; Togao, Osamu; Yoshioka, Kazuko; Tomita, Mayumi; Kuroki, Toshihide; Kanba, Shigenobu.
In: Depression and Anxiety, Vol. 26, No. 9, 01.09.2009, p. 814-823.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Duration effect of obsessive-compulsive disorder on cognitive function
T2 - A functional MRI study
AU - Nakao, Tomohiro
AU - Nakagawa, Akiko
AU - Yoshiura, Takashi
AU - Nakatani, Eriko
AU - Nabeyama, Maiko
AU - Sanematsu, Hirokuni
AU - Togao, Osamu
AU - Yoshioka, Kazuko
AU - Tomita, Mayumi
AU - Kuroki, Toshihide
AU - Kanba, Shigenobu
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Background: The inconsistency of previous reports examining cognitive function in obsessive-compulsive disorder (OCD) suggests its heterogeneity. In this study, we examined the effect of illness duration on cognitive function in OCD. Methods: We examined the cognitive function of 32 OCD patients and 16 healthy volunteers by neuropsychological tests and functional magnetic resonance imaging while they performed the Stroop and N-back tasks to assess attention and nonverbal memory. The patients were divided into two groups by illness duration: a short-term group (n=17, 5.5±3.1 years) and a long-term group (n=15, 20.3±6.1 years). Statistical analysis was performed to determine the differences between these two groups and the normal control group (n=16). Results: The long-term group showed attention deficit and nonverbal memory dysfunction on the neuropsychological tests. In contrast, on functional magnetic resonance imaging, the short-term group showed weaker activation of the right caudate during the Stroop task and stronger activation of the right dorso-lateral prefrontal cortex during the N-back task than the long-term and normal control groups. Conclusions: The results suggested that abnormal brain activation occurs in the early phase of OCD and that the long-term persistence of OCD might involve a decline in cognitive function.
AB - Background: The inconsistency of previous reports examining cognitive function in obsessive-compulsive disorder (OCD) suggests its heterogeneity. In this study, we examined the effect of illness duration on cognitive function in OCD. Methods: We examined the cognitive function of 32 OCD patients and 16 healthy volunteers by neuropsychological tests and functional magnetic resonance imaging while they performed the Stroop and N-back tasks to assess attention and nonverbal memory. The patients were divided into two groups by illness duration: a short-term group (n=17, 5.5±3.1 years) and a long-term group (n=15, 20.3±6.1 years). Statistical analysis was performed to determine the differences between these two groups and the normal control group (n=16). Results: The long-term group showed attention deficit and nonverbal memory dysfunction on the neuropsychological tests. In contrast, on functional magnetic resonance imaging, the short-term group showed weaker activation of the right caudate during the Stroop task and stronger activation of the right dorso-lateral prefrontal cortex during the N-back task than the long-term and normal control groups. Conclusions: The results suggested that abnormal brain activation occurs in the early phase of OCD and that the long-term persistence of OCD might involve a decline in cognitive function.
UR - http://www.scopus.com/inward/record.url?scp=70349129997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349129997&partnerID=8YFLogxK
U2 - 10.1002/da.20484
DO - 10.1002/da.20484
M3 - Article
C2 - 19105218
AN - SCOPUS:70349129997
VL - 26
SP - 814
EP - 823
JO - Depression and Anxiety
JF - Depression and Anxiety
SN - 1091-4269
IS - 9
ER -