Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats

Tomomi Nagayama, Yoshitaka Hirooka, Akiko Chishaki, Masao Takemoto, Yasushi Mukai, Shujiro Inoue, Takuya Kishi, Kenji Sunagawa

Research output: Contribution to journalArticle

Abstract

Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats

. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage.

Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus.

Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.

Original languageEnglish
Article number980505
JournalInternational Journal of Hypertension
Volume2014
DOIs
Publication statusPublished - 2014

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Atrial Fibrillation
Hypertension
Inbred SHR Rats
Blood Pressure
Inbred WKY Rats
Antihypertensive Agents
Arterial Pressure

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats. / Nagayama, Tomomi; Hirooka, Yoshitaka; Chishaki, Akiko; Takemoto, Masao; Mukai, Yasushi; Inoue, Shujiro; Kishi, Takuya; Sunagawa, Kenji.

In: International Journal of Hypertension, Vol. 2014, 980505, 2014.

Research output: Contribution to journalArticle

Nagayama, Tomomi ; Hirooka, Yoshitaka ; Chishaki, Akiko ; Takemoto, Masao ; Mukai, Yasushi ; Inoue, Shujiro ; Kishi, Takuya ; Sunagawa, Kenji. / Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats. In: International Journal of Hypertension. 2014 ; Vol. 2014.
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AU - Nagayama, Tomomi

AU - Hirooka, Yoshitaka

AU - Chishaki, Akiko

AU - Takemoto, Masao

AU - Mukai, Yasushi

AU - Inoue, Shujiro

AU - Kishi, Takuya

AU - Sunagawa, Kenji

PY - 2014

Y1 - 2014

N2 - Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage.Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus.Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.

AB - Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage.Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus.Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.

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