Duration of fever and PA/I38X-substituted virus emergence in patients treated with baloxavir in the 2018–2019 influenza season

Hideyuki Ikematsu, Naoki Kawai, Naoki Tani, Yong Chong, Norio Iwaki, Takuma Bando, Osame Tanaka, Shinro Matsuura, Tetsunari Maeda, Kenichi Doniwa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Duration of fever and virus persistence after baloxavir administration were investigated in 81 outpatients, 16 with A(H1N1)pdm09 and 65 with A(H3N2) in the Japanese 2018–2019 influenza season. Only eight cases of A(H3N2) viruses were detected post-dose. PA/I38T-substituted viruses were detected in four (6.2%) of 65 A(H3N2) patients, at days 3 and 4, constituting 50% (4/8) of A(H3N2) detected post-dose. The median duration of fever was 26.0 h for A(H1N1)pdm09 and 20.3 h for A(H3N2). The median duration of fever for patients with PA/I38T-substituted viruses was 22.0 h, without significant difference to that of the patients in whom the mutated virus was not detected. Emergence of PA/I38T-substituted viruses after treatment with baloxavir was confirmed, but no significant prolongation of fever was observed in the four patients with PA/I38T-substituted virus emergence.

Original languageEnglish
Pages (from-to)400-402
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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