Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain

Masato Yoshizawa, Masaki Sone, Naoki Matsuo, Takahiro Nagase, Osamu Ohara, Yo Ichi Nabeshima, Mikio Hoshino

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Dbl-family guanine nucleotide exchange factors (Dbl-GEFs) act as activators of Rho-like small G proteins such as Rac1, Cdc42 and RhoA. Recently, some GEFs have been suggested to play important roles in the development of the nervous system. Here, we report a comprehensive expression profile analysis of 20 Dbl-GEFs that have yet to be well investigated. Northern analyses of murine mRNAs from brains of E13, E17, P7 and adult mice revealed expression of 18 out of 20 GEFs in some or all stages. In addition, we found that three human GEFs were highly expressed in the brain. Examination of the spatial expression patterns of five GEFs in embryos or neonatal brain by in situ hybridization revealed distinct patterns for each GEF. Our study reveals the dynamic and coordinated expression profiles of the Dbl-GEFs and provides a basic framework for understanding the function of GEFs in neural development.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalGene Expression Patterns
Volume3
Issue number3
DOIs
Publication statusPublished - Jun 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Developmental Biology

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