Dynamic behavior of enzymatic system realizing two-factor model

Masahiro Okamoto, Atsuko Katsurayama, Michiko Tsukiji, Yoichi Aso, Katsuya Hayashi

Research output: Contribution to journalArticle

18 Citations (Scopus)


It has been shown that the two-factor model, introduced by Rosen for biological automata, could be realized at a molecular level by an enzymatic conjugate system. This system was applied to several metabolic regulatory models, and the dynamic behaviors were followed by computer simulation. It was revealed that the feedback system including the two-factor realizing system as a control element can maintain the stationary value of end product at a desired level against an external perturbation.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalJournal of Theoretical Biology
Issue number1
Publication statusPublished - Mar 7 1980


All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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